The first total synthesis of bifidenone, a novel natural tubulin polymerization inhibitor, has been achieved in 12 steps starting from commercially available starting materials. Bifidenone is the plant compound that inspired SQ1274, Sequoia's compound in development as an anticancer compound.
Citation: A Total Synthesis of Bifidenone. Zhongping Huang, Russell B. Williams, Mark O’Neil-Johnson, Gary R. Eldridge, John E. Mangette, and Courtney M. Starks. The Journal of Organic Chemistry 2017 82 (8), 4235-4241. DOI: 10.1021/acs.joc.7b00202