Sequoia has the most advanced NMR technologies used to rapidly generate spectroscopic data for structure determination. Utilizing the CapNMR™ Probe technology shown in Figure 1, Sequoia can rapidly elucidate the structures of biologically-active compounds on microgram quantities of material. For example, we published the novel stilbenes shown in Figure 2 in 2007 isolated from an orchid acquiring NMR spectra on microgram quantities of material.

Figure 1

Figure 2

Examples of NMR Spectra

Less than 10 micrograms of material (90% purity) is needed to acquire 1-D proton and 2-D TOCSY data sets.

Click to see Sequoia's data:
Proton: 1 microgram of Ginsenoside Rc in 5 microliters MeOH,d₄
TOCSY: 1 microgram of Ginsenoside Rc in 5 microliters MeOH,d₄

 Less than 50 micrograms of material (90% purity) is needed to acquire HMBC & HMQC data sets.

Click to see Sequoia's data:
HMQC: 30 micrograms of Muristerone A in 5 microliters Methanol-d₄
HMBC: 30 micrograms of Muristerone A in 5 microliters Methanol-d₄