Advanced Chemistry Technologies
Sequoia has the most advanced NMR technologies used to rapidly generate spectroscopic data for structure determination. Utilizing the CapNMR Probe technology shown in Figure 1, Sequoia can rapidly elucidate the structures of biologically-active compounds on microgram quantities of material. For example, we published the novel stilbenes shown in Figure 2 in 2007 isolated from an orchid acquiring NMR spectra on microgram quantities of material.
Figure 1

Figure 2

Examples of NMR Spectra
Less than 10 micrograms of material (90% purity) is needed to acquire 1-D proton and 2-D TOCSY data sets.
Click to see Sequoia's data:
Proton: 1 microgram of Ginsenoside Rc in 5 microliters MeOH,d4
TOCSY: 1 microgram of Ginsenoside Rc in 5 microliters MeOH,d4
Less than 50 micrograms of material (90% purity) is needed to acquire HMBC & HMQC data sets.
Click to see Sequoia's data:
HMQC: 30 micrograms of Muristerone A in 5 microliters Methanol-d4
HMBC: 30 micrograms of Muristerone A in 5 microliters Methanol-d4
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