Sequoia Sciences
Sequoia Sciences Sequoia Sciences
High-throughput Natural Products Chemistry

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Sequoia Sciences is a pharmaceutical company discovering and developing new medicines for the treatment of bacterial infections and cancers. Our development programs consist of small molecules targeting bacterial infections and cancers, and also vaccines for the treatment and prevention of recurrent urinary tract infections. Our goal is to improve the quality of life for those individuals significantly affected by recurrent and chronic bacterial infections and cancers.

Sequoia is engaged in research and development programs and collaborations with laboratories, universities, clinical research sites, and private businesses.  We have applied our microscale structure determination expertise to elucidate structures of natural products,  biosynthetic intermediates, and unexpected synthetic products for academic and industrial collaborators.  Contact us to determine the structure of your challenging compound.

Presentations | See All

Sequoia Sciences to lead a one day workshop on advanced analytical instrumentation, prior to the annual meeting of the American Society of Pharmacognosy.

Mark O'Neil-Johnson, VP of Analytical Chemistry, will organize and lead a full day workshop, "Advanced Analytical Technologies as Applied to Natural Products Research," prior to the 2015 meeting of the American Society of Pharmacognosy (ASP) in Copper Mountain, CO, July 25-29, 2015. The workshop will have the participation of the major analytical instrument vendors, presenting the science and techniques of taking a biomass to a molecular structure. Click here to view an abstract of this workshop.

Sequoia Sciences to lead a pre Congress symposia on advanced analytical instrumentation, prior to the 63rd annual meeting of the Society for Medicinal Plant and Natural Product Research.

Mark O'Neil-Johnson, VP of Analytical Chemistry, will organize and lead a full day pre Congress symposia, "Advanced Analytical Technologies as Applied to Natural Products Research," prior to the 63rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in Budapest, Hungary, August 23-27, 2015. The workshop will have the participation of the major analytical instrument vendors, presenting the science and techniques of taking a biomass to a molecular structure.

Sequoia Sciences to organize a 4 day symposia, The Interface of Science and Technology as Applied to Natural Product Research, as part of the Fusion Conferences Limited series of conferences.

Mark O'Neil-Johnson, VP of Analytical Chemistry, will organize and lead a 4 day conference, "The Interface of Science and Technology as Applied to Natural Products Research," in Budapest, Hungary, December 4-7, 2015. This is the second in a series of natural product conferences organized by Fusion Conferences Limited. The topics of the conference will cover areas of natural product synthesis, biosynthetic pathways, marine natural products, software and hardware, a special tribute to women in natural product chemistry and a unique lecture on the Rosetta satellite studying the comet 67P/Churyumov-Gerasimenko.


Recent Publications | See All

August, 2015: Williams, R., Norman, V., O'Neil-Johnson, M., Woodbury, S., Eldridge, G., Starks, C., "Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum," Journal of Natural Products, 2015, Accepted

July, 2015: Augustin, M., Ruzicka, D., Shukla, A., Augustin, J., Starks, C., O'Neil-Johnson, M., McKain, M., Evans, B., Barrett, M., Smithson, A., Wong, G., Deyholos, M., Edger, P., Pires, J., Leebens-Mack, J., Mann, D., Kutchan, T., "Elucidating Steroid Alkaloid Biosynthesis in Veratrum californicum: Production of Verazine in Sf9 Cells," The Plant Journal, 2015, 82, 991-1003 - Identifying Biosynthetic Intermediates at the Microgram Scale

April, 2015: Zerbe, P., Rodriguez, S., Mafu, S., Chaing, A., Dullat, H., O'Neil-Johnson, M., Starks, C., Bohlmann, J., "Exploring Diterpene Metabolism in Non-Model Species: Transcriptome-Enabled Discovery and Functional Characterization of Labda-7,13E-Dienyl Diphosphate Synthase from Grindelia robusta," The Plant Journal, 2015, Accepted - Identifying Biosynthetic Intermediates at the Microgram Scale

March, 2015: Chemler, J., Tropathi. A., Hansen, D., O'Neil-Johnson, M., Williams, R., Starks, C., Park, S., Sherman, D., "Evolution of Efficient Modular Polyketide Synthases by Homeologous Recombination," JACS, 2015, Accepted - Identifying Biosynthetic Intermediates at the Microgram Scale